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3D-printed PLA medical devices: physicochemical changes and biological response after sterilisation treatments

Identificadores del recurso

Polymers, 14(19): 4117 (2022)

20734360

http://hdl.handle.net/11093/3951

10.3390/polym14194117

https://www.mdpi.com/2073-4360/14/19/4117

Procedencia

(Investigo)

Ficha

Título:: 3D-printed PLA medical devices: physicochemical changes and biological response after sterilisation treatments
Tema:: 2206.10 Polímeros; 3314 Tecnología Médica; 2210 Química Física
Descripción:: Financiado para publicación en acceso aberto: Universidade de Vigo/CISUG; Polylactic acid (PLA) has become one of the most commonly used polymers in medical devices given its biocompatible, biodegradable and bioabsorbable properties. In addition, due to PLA’s thermoplastic behaviour, these medical devices are now obtained using 3D printing technologies. Once obtained, the 3D-printed PLA devices undergo different sterilisation procedures, which are essential to prevent infections. This work was an in-depth study of the physicochemical changes caused by novel and conventional sterilisation techniques on 3D-printed PLA and their impact on the biological response in terms of toxicity. The 3D-printed PLA physicochemical (XPS, FTIR, DSC, XRD) and mechanical properties as well as the hydrophilic degree were evaluated after sterilisation using saturated steam (SS), low temperature steam with formaldehyde (LTSF), gamma irradiation (GR), hydrogen peroxide gas plasma (HPGP) and CO2 under critical conditions (SCCO). The biological response was tested in vitro (fibroblasts NCTC-929) and in vivo (embryos and larvae wild-type zebrafish Danio rerio). The results indicated that after GR sterilisation, PLA preserved the O:C ratio and the semi-crystalline structure. Significant changes in the polymer surface were found after HPGP, LTSF and SS sterilisations, with a decrease in the O:C ratio. Moreover, the FTIR, DSC and XRD analysis revealed PLA crystallisation after SS sterilisation, with a 52.9% increase in the crystallinity index. This structural change was also reflected in the mechanical properties and wettability. An increase in crystallinity was also observed after SCCO and LTSF sterilisations, although to a lesser extent. Despite these changes, the biological evaluation revealed that none of the techniques were shown to promote the release of toxic compounds or PLA modifications with toxicity effects. GR sterilisation was concluded as the least reactive technique with good perspectives in the biological response, not only at the level of toxicity but at all levels, since the 3D-printed PLA remained almost unaltered.; POCTEP INTERREG España- Portugal | Ref. BLUEBIOLAB; Interreg Atlantic Area | Ref. BLUEHUMAN EAPA_151/2016; Ministerio de Ciencia e Innovación | Ref. PID 2020-115415RB-100; Xunta de Galicia | Ref. ED431C 2021/49; Xunta de Galicia | Ref. ED481A 2019/314; Xunta de Galicia | Ref. IN606A-2017/011; Fundação para a Ciência e a Tecnologia | Ref. UIDB/50016/2020
Idioma:: English
Relación:: info:eu-repo/grantAgreement/MICINN//PID2020-115415RB-100/ES
Autor/Productor:: Pérez Davila, Sara; González Rodríguez, Laura; Lama, Raquel; López Álvarez, Miriam; Oliveira, Ana Leite; Serra Rodríguez, Julia Asunción; Novoa, Beatriz; Figueras, Antonio; González Fernández, Pío Manuel
Editor:: Polymers; Física aplicada; Novos Materiais
Derechos:: Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/; openAccess
Fecha:: 2022-10-17T10:33:25Z; 2022-10-01; 2022-10-17T10:27:29Z
Tipo de recurso:: article

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1. < dc:title > 3D-printed PLA medical devices: physicochemical changes and biological response after sterilisation treatments </ dc:title >
2. < dc:creator > Pérez Davila, Sara </ dc:creator >
3. < dc:creator > González Rodríguez, Laura </ dc:creator >
4. < dc:creator > Lama, Raquel </ dc:creator >
5. < dc:creator > López Álvarez, Miriam </ dc:creator >
6. < dc:creator > Oliveira, Ana Leite </ dc:creator >
7. < dc:creator > Serra Rodríguez, Julia Asunción </ dc:creator >
8. < dc:creator > Novoa, Beatriz </ dc:creator >
9. < dc:creator > Figueras, Antonio </ dc:creator >
10. < dc:creator > González Fernández, Pío Manuel </ dc:creator >
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12. < dc:subject > 3314 Tecnología Médica </ dc:subject >
13. < dc:subject > 2210 Química Física </ dc:subject >
14. < dc:description > Financiado para publicación en acceso aberto: Universidade de Vigo/CISUG </ dc:description >
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2. < creator > Pérez Davila, Sara </ creator >
3. < creator > González Rodríguez, Laura </ creator >
4. < creator > Lama, Raquel </ creator >
5. < creator > López Álvarez, Miriam </ creator >
6. < creator > Oliveira, Ana Leite </ creator >
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10. < creator > González Fernández, Pío Manuel </ creator >
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12. < description > Polylactic acid (PLA) has become one of the most commonly used polymers in medical devices given its biocompatible, biodegradable and bioabsorbable properties. In addition, due to PLA’s thermoplastic behaviour, these medical devices are now obtained using 3D printing technologies. Once obtained, the 3D-printed PLA devices undergo different sterilisation procedures, which are essential to prevent infections. This work was an in-depth study of the physicochemical changes caused by novel and conventional sterilisation techniques on 3D-printed PLA and their impact on the biological response in terms of toxicity. The 3D-printed PLA physicochemical (XPS, FTIR, DSC, XRD) and mechanical properties as well as the hydrophilic degree were evaluated after sterilisation using saturated steam (SS), low temperature steam with formaldehyde (LTSF), gamma irradiation (GR), hydrogen peroxide gas plasma (HPGP) and CO2 under critical conditions (SCCO). The biological response was tested in vitro (fibroblasts NCTC-929) and in vivo (embryos and larvae wild-type zebrafish Danio rerio). The results indicated that after GR sterilisation, PLA preserved the O:C ratio and the semi-crystalline structure. Significant changes in the polymer surface were found after HPGP, LTSF and SS sterilisations, with a decrease in the O:C ratio. Moreover, the FTIR, DSC and XRD analysis revealed PLA crystallisation after SS sterilisation, with a 52.9% increase in the crystallinity index. This structural change was also reflected in the mechanical properties and wettability. An increase in crystallinity was also observed after SCCO and LTSF sterilisations, although to a lesser extent. Despite these changes, the biological evaluation revealed that none of the techniques were shown to promote the release of toxic compounds or PLA modifications with toxicity effects. GR sterilisation was concluded as the least reactive technique with good perspectives in the biological response, not only at the level of toxicity but at all levels, since the 3D-printed PLA remained almost unaltered. </ description >
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1. < dc:title > 3D-printed PLA medical devices: physicochemical changes and biological response after sterilisation treatments </ dc:title >
2. < dc:creator > Pérez Davila, Sara </ dc:creator >
3. < dc:creator > González Rodríguez, Laura </ dc:creator >
4. < dc:creator > Lama, Raquel </ dc:creator >
5. < dc:creator > López Álvarez, Miriam </ dc:creator >
6. < dc:creator > Oliveira, Ana Leite </ dc:creator >
7. < dc:creator > Serra Rodríguez, Julia Asunción </ dc:creator >
8. < dc:creator > Novoa, Beatriz </ dc:creator >
9. < dc:creator > Figueras, Antonio </ dc:creator >
10. < dc:creator > González Fernández, Pío Manuel </ dc:creator >
11. < dcterms:abstract > Polylactic acid (PLA) has become one of the most commonly used polymers in medical devices given its biocompatible, biodegradable and bioabsorbable properties. In addition, due to PLA’s thermoplastic behaviour, these medical devices are now obtained using 3D printing technologies. Once obtained, the 3D-printed PLA devices undergo different sterilisation procedures, which are essential to prevent infections. This work was an in-depth study of the physicochemical changes caused by novel and conventional sterilisation techniques on 3D-printed PLA and their impact on the biological response in terms of toxicity. The 3D-printed PLA physicochemical (XPS, FTIR, DSC, XRD) and mechanical properties as well as the hydrophilic degree were evaluated after sterilisation using saturated steam (SS), low temperature steam with formaldehyde (LTSF), gamma irradiation (GR), hydrogen peroxide gas plasma (HPGP) and CO2 under critical conditions (SCCO). The biological response was tested in vitro (fibroblasts NCTC-929) and in vivo (embryos and larvae wild-type zebrafish Danio rerio). The results indicated that after GR sterilisation, PLA preserved the O:C ratio and the semi-crystalline structure. Significant changes in the polymer surface were found after HPGP, LTSF and SS sterilisations, with a decrease in the O:C ratio. Moreover, the FTIR, DSC and XRD analysis revealed PLA crystallisation after SS sterilisation, with a 52.9% increase in the crystallinity index. This structural change was also reflected in the mechanical properties and wettability. An increase in crystallinity was also observed after SCCO and LTSF sterilisations, although to a lesser extent. Despite these changes, the biological evaluation revealed that none of the techniques were shown to promote the release of toxic compounds or PLA modifications with toxicity effects. GR sterilisation was concluded as the least reactive technique with good perspectives in the biological response, not only at the level of toxicity but at all levels, since the 3D-printed PLA remained almost unaltered. </ dcterms:abstract >
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  9. < dc:creator > Figueras, Antonio </ dc:creator >
  10. < dc:creator > González Fernández, Pío Manuel </ dc:creator >
  11. < dc:description > Financiado para publicación en acceso aberto: Universidade de Vigo/CISUG </ dc:description >
  12. < dc:description > Polylactic acid (PLA) has become one of the most commonly used polymers in medical devices given its biocompatible, biodegradable and bioabsorbable properties. In addition, due to PLA’s thermoplastic behaviour, these medical devices are now obtained using 3D printing technologies. Once obtained, the 3D-printed PLA devices undergo different sterilisation procedures, which are essential to prevent infections. This work was an in-depth study of the physicochemical changes caused by novel and conventional sterilisation techniques on 3D-printed PLA and their impact on the biological response in terms of toxicity. The 3D-printed PLA physicochemical (XPS, FTIR, DSC, XRD) and mechanical properties as well as the hydrophilic degree were evaluated after sterilisation using saturated steam (SS), low temperature steam with formaldehyde (LTSF), gamma irradiation (GR), hydrogen peroxide gas plasma (HPGP) and CO2 under critical conditions (SCCO). The biological response was tested in vitro (fibroblasts NCTC-929) and in vivo (embryos and larvae wild-type zebrafish Danio rerio). The results indicated that after GR sterilisation, PLA preserved the O:C ratio and the semi-crystalline structure. Significant changes in the polymer surface were found after HPGP, LTSF and SS sterilisations, with a decrease in the O:C ratio. Moreover, the FTIR, DSC and XRD analysis revealed PLA crystallisation after SS sterilisation, with a 52.9% increase in the crystallinity index. This structural change was also reflected in the mechanical properties and wettability. An increase in crystallinity was also observed after SCCO and LTSF sterilisations, although to a lesser extent. Despite these changes, the biological evaluation revealed that none of the techniques were shown to promote the release of toxic compounds or PLA modifications with toxicity effects. GR sterilisation was concluded as the least reactive technique with good perspectives in the biological response, not only at the level of toxicity but at all levels, since the 3D-printed PLA remained almost unaltered. </ dc:description >
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10. < dcterms:abstract lang =" en " > Polylactic acid (PLA) has become one of the most commonly used polymers in medical devices given its biocompatible, biodegradable and bioabsorbable properties. In addition, due to PLA’s thermoplastic behaviour, these medical devices are now obtained using 3D printing technologies. Once obtained, the 3D-printed PLA devices undergo different sterilisation procedures, which are essential to prevent infections. This work was an in-depth study of the physicochemical changes caused by novel and conventional sterilisation techniques on 3D-printed PLA and their impact on the biological response in terms of toxicity. The 3D-printed PLA physicochemical (XPS, FTIR, DSC, XRD) and mechanical properties as well as the hydrophilic degree were evaluated after sterilisation using saturated steam (SS), low temperature steam with formaldehyde (LTSF), gamma irradiation (GR), hydrogen peroxide gas plasma (HPGP) and CO2 under critical conditions (SCCO). The biological response was tested in vitro (fibroblasts NCTC-929) and in vivo (embryos and larvae wild-type zebrafish Danio rerio). The results indicated that after GR sterilisation, PLA preserved the O:C ratio and the semi-crystalline structure. Significant changes in the polymer surface were found after HPGP, LTSF and SS sterilisations, with a decrease in the O:C ratio. Moreover, the FTIR, DSC and XRD analysis revealed PLA crystallisation after SS sterilisation, with a 52.9% increase in the crystallinity index. This structural change was also reflected in the mechanical properties and wettability. An increase in crystallinity was also observed after SCCO and LTSF sterilisations, although to a lesser extent. Despite these changes, the biological evaluation revealed that none of the techniques were shown to promote the release of toxic compounds or PLA modifications with toxicity effects. GR sterilisation was concluded as the least reactive technique with good perspectives in the biological response, not only at the level of toxicity but at all levels, since the 3D-printed PLA remained almost unaltered. </ dcterms:abstract >
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