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Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study

Identificadores del recurso

Lasarte-Monterrubio Cristina, Guijarro-Sánchez Paula, Alonso-Garcia Isaac, Outeda Michelle, Maceiras Romina, González-Pinto Lucia, Martínez-Guitián Marta, Fernández-Lozano Carlos, Vázquez-Ucha Juan Carlos, Bou German, Arca-Suárez Jorge, Beceiro Alejandro. Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study. Euro Surveill. 2024;29(15):pii=2300352. https://doi.org/10.2807/1560-7917.ES.2024.29.15.2300352

1560-7917

http://hdl.handle.net/2183/37791

Procedencia

(RUC. Repositorio da Universidade da Coruña)

Ficha

Título:: Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study
Tema:: Acinetobacter baumannii; Carbapenem-resistant; OXA-23; Nosocomial infections
Descrición:: [Abstract]: Background: As increasing antibiotic resistance in Acinetobacter baumannii poses a global healthcare challenge, understanding its evolution is crucial for effective control strategies. Aim: We aimed to evaluate the epidemiology, antimicrobial susceptibility and main resistance mechanisms of Acinetobacter spp. in Spain in 2020, and to explore temporal trends of A. baumannii. Methods: We collected 199 single-patient Acinetobacter spp. clinical isolates in 2020 from 18 Spanish tertiary hospitals. Minimum inhibitory concentrations (MICs) for nine antimicrobials were determined. Short-read sequencing was performed for all isolates, and targeted long-read sequencing for A. baumannii. Resistance mechanisms, phylogenetics and clonality were assessed. Findings on resistance rates and infection types were compared with data from 2000 and 2010. Results: Cefiderocol and colistin exhibited the highest activity against A. baumannii, although colistin susceptibility has significantly declined over 2 decades. A. non-baumannii strains were highly susceptible to most tested antibiotics. Of the A. baumannii isolates, 47.5% (56/118) were multidrug-resistant (MDR). Phylogeny and clonal relationship analysis of A. baumannii revealed five prevalent international clones, notably IC2 (ST2, n = 52; ST745, n = 4) and IC1 (ST1, n = 14), and some episodes of clonal dissemination. Genes blaOXA-23, blaOXA-58 and blaOXA-24/40 were identified in 49 (41.5%), eight (6.8%) and one (0.8%) A. baumannii isolates, respectively. ISAba1 was found upstream of the gene (a blaOXA-51-like) in 10 isolates. Conclusions: The emergence of OXA-23-producing ST1 and ST2, the predominant MDR lineages, shows a pivotal shift in carbapenem-resistant A. baumannii (CRAB) epidemiology in Spain. Coupled with increased colistin resistance, these changes underscore notable alterations in regional antimicrobial resistance dynamics.; This work was supported by Projects PI20/01212 and PI23/00851 awarded to AB, Project PI21/00704 awarded to GB, and Project PI22/01212 awarded to JA-S, funded by the Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union. The work was also supported by CIBER-Consorcio Centro de Investigación Biomédica en Red- de Enfermedades Infecciosas, Instituto de Salud Carlos III (CB21/13/00055), Ministerio de Ciencia e Innovación and Unión Europea—NextGenerationEU and by project IN607A 2020/05 (GAIN-Agencia Gallega de InnovaciónConsellería de Economía, Emprego e Industria) awarded to GB and project IN607D 2021/12 awarded to AB. JA-S was financially supported by the Juan Rodés program (ISCIII, JR21/00026), JCV-U was financially supported by IN606B-2022/009 (Xunta de Galicia), CL-M was financially supported by PI20/01212 (ISCIII), PG-S was financially supported by IN606A 2021/021 Grant (Xunta de Galicia). MO was financially supported by IN607D 2021/12. IA-G was financially supported by the Rio Hortega program (ISCIII, CM21/00076). MM-G was financially supported by RSU.UDC.M505 (Ministerio de Universidades).; Xunta de Galicia; IN607A 2020/05; Xunta de Galicia; IN607D 2021/12; Xunta de Galicia; IN606B-2022/009; Xunta de Galicia; IN606A 2021/021; Universidade da Coruña; RSU.UDC.M505
Idioma:: English
Relación:: info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F01212/ES/DESARROLLO Y EVALUACION DE NUEVAS MOLECULAS ANTIMICROBIANAS DIRIGIDAS A PATOGENOS MULTIRRESISTENTES (INHIBIDORES DE ß-LACTAMASAS Y CONJUGADOS TETRACICLINAS-SIDEROFOROS). ESTUDIO NACIONAL ACINETOBACTER SPP/; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PI23%2F00851/ES/Actividad in vivo de nuevos inhibidores de carbapenemasas frente a patógenos críticos multirresistentes: K. pneumoniae productor de carbapenemasas y P. aeruginosa.; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI21%2F00704/ES/VACUNAS AUXOTROFAS ORALES PARA LA ERRADICACION DE BACTERIAS INTESTINALES: COLONIZACIÓN INTESTINAL POR KLEBSIELLA PNEUMONIAE MULTIRRESISTENTE COMO MODELO/; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PI22%2F01212/ES/INHIBIDORES DE CARBAPENEMASAS: ACTIVIDAD FRENTE A ENTEROBACTERALES PRODUCTORES DE CARBAPENEMASAS, MECANISMOS E IMPACTO EN LA EVOLUCIÓN DE LA RESISTENCIA ANTIMICROBIANA (PROTECT); info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CB21%2F13%2F00055/ES/CIBERINFEC/; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CM21%2F00076/ES/; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/JR21%2F00026/ES/; https://doi.org/10.2807/1560-7917.ES.2024.29.15.2300352
Autor/Produtor:: Lasarte-Monterrubio, Cristina; Guijarro, Paula; Alonso-Garcia, Isaac; Outeda, Michelle; Maceiras, Romina; González-Pinto, Lucía; Martínez-Guitián, Marta; Fernández-Lozano, Carlos; Vázquez-Ucha, Juan Carlos; Bou, Germán; Arca-Suárez, Jorge; Beceiro, Alejandro
Editor:: European Centre for Disease Prevention and Control (ECDC)
Dereitos:: Atribución 3.0 España; http://creativecommons.org/licenses/by/3.0/es/; info:eu-repo/semantics/openAccess
Data:: 2024-04-11
Tipo de recurso:: info:eu-repo/semantics/article

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1. < dc:title > Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study </ dc:title >
2. < dc:creator > Lasarte-Monterrubio, Cristina </ dc:creator >
3. < dc:creator > Guijarro, Paula </ dc:creator >
4. < dc:creator > Alonso-Garcia, Isaac </ dc:creator >
5. < dc:creator > Outeda, Michelle </ dc:creator >
6. < dc:creator > Maceiras, Romina </ dc:creator >
7. < dc:creator > González-Pinto, Lucía </ dc:creator >
8. < dc:creator > Martínez-Guitián, Marta </ dc:creator >
9. < dc:creator > Fernández-Lozano, Carlos </ dc:creator >
10. < dc:creator > Vázquez-Ucha, Juan Carlos </ dc:creator >
11. < dc:creator > Bou, Germán </ dc:creator >
12. < dc:creator > Arca-Suárez, Jorge </ dc:creator >
13. < dc:creator > Beceiro, Alejandro </ dc:creator >
14. < dc:subject > Acinetobacter baumannii </ dc:subject >
15. < dc:subject > Carbapenem-resistant </ dc:subject >
16. < dc:subject > OXA-23 </ dc:subject >
17. < dc:subject > Nosocomial infections </ dc:subject >
18. < dc:description > [Abstract]: Background: As increasing antibiotic resistance in Acinetobacter baumannii poses a global healthcare challenge, understanding its evolution is crucial for effective control strategies. Aim: We aimed to evaluate the epidemiology, antimicrobial susceptibility and main resistance mechanisms of Acinetobacter spp. in Spain in 2020, and to explore temporal trends of A. baumannii. Methods: We collected 199 single-patient Acinetobacter spp. clinical isolates in 2020 from 18 Spanish tertiary hospitals. Minimum inhibitory concentrations (MICs) for nine antimicrobials were determined. Short-read sequencing was performed for all isolates, and targeted long-read sequencing for A. baumannii. Resistance mechanisms, phylogenetics and clonality were assessed. Findings on resistance rates and infection types were compared with data from 2000 and 2010. Results: Cefiderocol and colistin exhibited the highest activity against A. baumannii, although colistin susceptibility has significantly declined over 2 decades. A. non-baumannii strains were highly susceptible to most tested antibiotics. Of the A. baumannii isolates, 47.5% (56/118) were multidrug-resistant (MDR). Phylogeny and clonal relationship analysis of A. baumannii revealed five prevalent international clones, notably IC2 (ST2, n = 52; ST745, n = 4) and IC1 (ST1, n = 14), and some episodes of clonal dissemination. Genes blaOXA-23, blaOXA-58 and blaOXA-24/40 were identified in 49 (41.5%), eight (6.8%) and one (0.8%) A. baumannii isolates, respectively. ISAba1 was found upstream of the gene (a blaOXA-51-like) in 10 isolates. Conclusions: The emergence of OXA-23-producing ST1 and ST2, the predominant MDR lineages, shows a pivotal shift in carbapenem-resistant A. baumannii (CRAB) epidemiology in Spain. Coupled with increased colistin resistance, these changes underscore notable alterations in regional antimicrobial resistance dynamics. </ dc:description >
19. < dc:description > This work was supported by Projects PI20/01212 and PI23/00851 awarded to AB, Project PI21/00704 awarded to GB, and Project PI22/01212 awarded to JA-S, funded by the Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union. The work was also supported by CIBER-Consorcio Centro de Investigación Biomédica en Red- de Enfermedades Infecciosas, Instituto de Salud Carlos III (CB21/13/00055), Ministerio de Ciencia e Innovación and Unión Europea—NextGenerationEU and by project IN607A 2020/05 (GAIN-Agencia Gallega de InnovaciónConsellería de Economía, Emprego e Industria) awarded to GB and project IN607D 2021/12 awarded to AB. JA-S was financially supported by the Juan Rodés program (ISCIII, JR21/00026), JCV-U was financially supported by IN606B-2022/009 (Xunta de Galicia), CL-M was financially supported by PI20/01212 (ISCIII), PG-S was financially supported by IN606A 2021/021 Grant (Xunta de Galicia). MO was financially supported by IN607D 2021/12. IA-G was financially supported by the Rio Hortega program (ISCIII, CM21/00076). MM-G was financially supported by RSU.UDC.M505 (Ministerio de Universidades). </ dc:description >
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26. < dc:date > 2024-04-11 </ dc:date >
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28. < dc:identifier > Lasarte-Monterrubio Cristina, Guijarro-Sánchez Paula, Alonso-Garcia Isaac, Outeda Michelle, Maceiras Romina, González-Pinto Lucia, Martínez-Guitián Marta, Fernández-Lozano Carlos, Vázquez-Ucha Juan Carlos, Bou German, Arca-Suárez Jorge, Beceiro Alejandro. Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study. Euro Surveill. 2024;29(15):pii=2300352. https://doi.org/10.2807/1560-7917.ES.2024.29.15.2300352 </ dc:identifier >
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        < dc:creator > Arca-Suárez, Jorge </ dc:creator >
        
        < dc:creator > Beceiro, Alejandro </ dc:creator >
        
        < dc:subject > Acinetobacter baumannii </ dc:subject >
        
        < dc:subject > Carbapenem-resistant </ dc:subject >
        
        < dc:subject > OXA-23 </ dc:subject >
        
        < dc:subject > Nosocomial infections </ dc:subject >
        
        < dc:description > [Abstract]: Background: As increasing antibiotic resistance in Acinetobacter baumannii poses a global healthcare challenge, understanding its evolution is crucial for effective control strategies. Aim: We aimed to evaluate the epidemiology, antimicrobial susceptibility and main resistance mechanisms of Acinetobacter spp. in Spain in 2020, and to explore temporal trends of A. baumannii. Methods: We collected 199 single-patient Acinetobacter spp. clinical isolates in 2020 from 18 Spanish tertiary hospitals. Minimum inhibitory concentrations (MICs) for nine antimicrobials were determined. Short-read sequencing was performed for all isolates, and targeted long-read sequencing for A. baumannii. Resistance mechanisms, phylogenetics and clonality were assessed. Findings on resistance rates and infection types were compared with data from 2000 and 2010. Results: Cefiderocol and colistin exhibited the highest activity against A. baumannii, although colistin susceptibility has significantly declined over 2 decades. A. non-baumannii strains were highly susceptible to most tested antibiotics. Of the A. baumannii isolates, 47.5% (56/118) were multidrug-resistant (MDR). Phylogeny and clonal relationship analysis of A. baumannii revealed five prevalent international clones, notably IC2 (ST2, n = 52; ST745, n = 4) and IC1 (ST1, n = 14), and some episodes of clonal dissemination. Genes blaOXA-23, blaOXA-58 and blaOXA-24/40 were identified in 49 (41.5%), eight (6.8%) and one (0.8%) A. baumannii isolates, respectively. ISAba1 was found upstream of the gene (a blaOXA-51-like) in 10 isolates. Conclusions: The emergence of OXA-23-producing ST1 and ST2, the predominant MDR lineages, shows a pivotal shift in carbapenem-resistant A. baumannii (CRAB) epidemiology in Spain. Coupled with increased colistin resistance, these changes underscore notable alterations in regional antimicrobial resistance dynamics. </ dc:description >
        
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16. < dim:field element =" identifier " lang =" es_ES " mdschema =" dc " qualifier =" citation " > Lasarte-Monterrubio Cristina, Guijarro-Sánchez Paula, Alonso-Garcia Isaac, Outeda Michelle, Maceiras Romina, González-Pinto Lucia, Martínez-Guitián Marta, Fernández-Lozano Carlos, Vázquez-Ucha Juan Carlos, Bou German, Arca-Suárez Jorge, Beceiro Alejandro. Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study. Euro Surveill. 2024;29(15):pii=2300352. https://doi.org/10.2807/1560-7917.ES.2024.29.15.2300352 </ dim:field >
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18. < dim:field element =" identifier " mdschema =" dc " qualifier =" uri " > http://hdl.handle.net/2183/37791 </ dim:field >
19. < dim:field element =" description " lang =" es_ES " mdschema =" dc " qualifier =" abstract " > [Abstract]: Background: As increasing antibiotic resistance in Acinetobacter baumannii poses a global healthcare challenge, understanding its evolution is crucial for effective control strategies. Aim: We aimed to evaluate the epidemiology, antimicrobial susceptibility and main resistance mechanisms of Acinetobacter spp. in Spain in 2020, and to explore temporal trends of A. baumannii. Methods: We collected 199 single-patient Acinetobacter spp. clinical isolates in 2020 from 18 Spanish tertiary hospitals. Minimum inhibitory concentrations (MICs) for nine antimicrobials were determined. Short-read sequencing was performed for all isolates, and targeted long-read sequencing for A. baumannii. Resistance mechanisms, phylogenetics and clonality were assessed. Findings on resistance rates and infection types were compared with data from 2000 and 2010. Results: Cefiderocol and colistin exhibited the highest activity against A. baumannii, although colistin susceptibility has significantly declined over 2 decades. A. non-baumannii strains were highly susceptible to most tested antibiotics. Of the A. baumannii isolates, 47.5% (56/118) were multidrug-resistant (MDR). Phylogeny and clonal relationship analysis of A. baumannii revealed five prevalent international clones, notably IC2 (ST2, n = 52; ST745, n = 4) and IC1 (ST1, n = 14), and some episodes of clonal dissemination. Genes blaOXA-23, blaOXA-58 and blaOXA-24/40 were identified in 49 (41.5%), eight (6.8%) and one (0.8%) A. baumannii isolates, respectively. ISAba1 was found upstream of the gene (a blaOXA-51-like) in 10 isolates. Conclusions: The emergence of OXA-23-producing ST1 and ST2, the predominant MDR lineages, shows a pivotal shift in carbapenem-resistant A. baumannii (CRAB) epidemiology in Spain. Coupled with increased colistin resistance, these changes underscore notable alterations in regional antimicrobial resistance dynamics. </ dim:field >
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23. < dim:field element =" description " lang =" es_ES " mdschema =" dc " qualifier =" sponsorship " > This work was supported by Projects PI20/01212 and PI23/00851 awarded to AB, Project PI21/00704 awarded to GB, and Project PI22/01212 awarded to JA-S, funded by the Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union. The work was also supported by CIBER-Consorcio Centro de Investigación Biomédica en Red- de Enfermedades Infecciosas, Instituto de Salud Carlos III (CB21/13/00055), Ministerio de Ciencia e Innovación and Unión Europea—NextGenerationEU and by project IN607A 2020/05 (GAIN-Agencia Gallega de InnovaciónConsellería de Economía, Emprego e Industria) awarded to GB and project IN607D 2021/12 awarded to AB. JA-S was financially supported by the Juan Rodés program (ISCIII, JR21/00026), JCV-U was financially supported by IN606B-2022/009 (Xunta de Galicia), CL-M was financially supported by PI20/01212 (ISCIII), PG-S was financially supported by IN606A 2021/021 Grant (Xunta de Galicia). MO was financially supported by IN607D 2021/12. IA-G was financially supported by the Rio Hortega program (ISCIII, CM21/00076). MM-G was financially supported by RSU.UDC.M505 (Ministerio de Universidades). </ dim:field >
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29. < dim:field element =" description " lang =" es_ES " mdschema =" dc " qualifier =" sponsorship " > Universidade da Coruña; RSU.UDC.M505 </ dim:field >
30. < dim:field element =" language " lang =" es_ES " mdschema =" dc " qualifier =" iso " > eng </ dim:field >
31. < dim:field element =" publisher " lang =" es_ES " mdschema =" dc " > European Centre for Disease Prevention and Control (ECDC) </ dim:field >
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47. < dim:field element =" title " lang =" es_ES " mdschema =" dc " > Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study </ dim:field >
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1. < title > Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study </ title >
2. < creator > Lasarte-Monterrubio, Cristina </ creator >
3. < creator > Guijarro, Paula </ creator >
4. < creator > Alonso-Garcia, Isaac </ creator >
5. < creator > Outeda, Michelle </ creator >
6. < creator > Maceiras, Romina </ creator >
7. < creator > González-Pinto, Lucía </ creator >
8. < creator > Martínez-Guitián, Marta </ creator >
9. < creator > Fernández-Lozano, Carlos </ creator >
10. < creator > Vázquez-Ucha, Juan Carlos </ creator >
11. < creator > Bou, Germán </ creator >
12. < creator > Arca-Suárez, Jorge </ creator >
13. < creator > Beceiro, Alejandro </ creator >
14. < subject > Acinetobacter baumannii </ subject >
15. < subject > Carbapenem-resistant </ subject >
16. < subject > OXA-23 </ subject >
17. < subject > Nosocomial infections </ subject >
18. < description > [Abstract]: Background: As increasing antibiotic resistance in Acinetobacter baumannii poses a global healthcare challenge, understanding its evolution is crucial for effective control strategies. Aim: We aimed to evaluate the epidemiology, antimicrobial susceptibility and main resistance mechanisms of Acinetobacter spp. in Spain in 2020, and to explore temporal trends of A. baumannii. Methods: We collected 199 single-patient Acinetobacter spp. clinical isolates in 2020 from 18 Spanish tertiary hospitals. Minimum inhibitory concentrations (MICs) for nine antimicrobials were determined. Short-read sequencing was performed for all isolates, and targeted long-read sequencing for A. baumannii. Resistance mechanisms, phylogenetics and clonality were assessed. Findings on resistance rates and infection types were compared with data from 2000 and 2010. Results: Cefiderocol and colistin exhibited the highest activity against A. baumannii, although colistin susceptibility has significantly declined over 2 decades. A. non-baumannii strains were highly susceptible to most tested antibiotics. Of the A. baumannii isolates, 47.5% (56/118) were multidrug-resistant (MDR). Phylogeny and clonal relationship analysis of A. baumannii revealed five prevalent international clones, notably IC2 (ST2, n = 52; ST745, n = 4) and IC1 (ST1, n = 14), and some episodes of clonal dissemination. Genes blaOXA-23, blaOXA-58 and blaOXA-24/40 were identified in 49 (41.5%), eight (6.8%) and one (0.8%) A. baumannii isolates, respectively. ISAba1 was found upstream of the gene (a blaOXA-51-like) in 10 isolates. Conclusions: The emergence of OXA-23-producing ST1 and ST2, the predominant MDR lineages, shows a pivotal shift in carbapenem-resistant A. baumannii (CRAB) epidemiology in Spain. Coupled with increased colistin resistance, these changes underscore notable alterations in regional antimicrobial resistance dynamics. </ description >
19. < date > 2024-07-08 </ date >
20. < date > 2024-07-08 </ date >
21. < date > 2024-04-11 </ date >
22. < type > info:eu-repo/semantics/article </ type >
23. < identifier > Lasarte-Monterrubio Cristina, Guijarro-Sánchez Paula, Alonso-Garcia Isaac, Outeda Michelle, Maceiras Romina, González-Pinto Lucia, Martínez-Guitián Marta, Fernández-Lozano Carlos, Vázquez-Ucha Juan Carlos, Bou German, Arca-Suárez Jorge, Beceiro Alejandro. Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study. Euro Surveill. 2024;29(15):pii=2300352. https://doi.org/10.2807/1560-7917.ES.2024.29.15.2300352 </ identifier >
24. < identifier > 1560-7917 </ identifier >
25. < identifier > http://hdl.handle.net/2183/37791 </ identifier >
26. < language > eng </ language >
27. < relation > https://doi.org/10.2807/1560-7917.ES.2024.29.15.2300352 </ relation >
28. < relation > info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F01212/ES/DESARROLLO Y EVALUACION DE NUEVAS MOLECULAS ANTIMICROBIANAS DIRIGIDAS A PATOGENOS MULTIRRESISTENTES (INHIBIDORES DE ß-LACTAMASAS Y CONJUGADOS TETRACICLINAS-SIDEROFOROS). ESTUDIO NACIONAL ACINETOBACTER SPP/ </ relation >
29. < relation > info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PI23%2F00851/ES/Actividad in vivo de nuevos inhibidores de carbapenemasas frente a patógenos críticos multirresistentes: K. pneumoniae productor de carbapenemasas y P. aeruginosa. </ relation >
30. < relation > info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI21%2F00704/ES/VACUNAS AUXOTROFAS ORALES PARA LA ERRADICACION DE BACTERIAS INTESTINALES: COLONIZACIÓN INTESTINAL POR KLEBSIELLA PNEUMONIAE MULTIRRESISTENTE COMO MODELO/ </ relation >
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32. < relation > info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CB21%2F13%2F00055/ES/CIBERINFEC/ </ relation >
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34. < relation > info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/JR21%2F00026/ES/ </ relation >
35. < rights > http://creativecommons.org/licenses/by/3.0/es/ </ rights >
36. < rights > info:eu-repo/semantics/openAccess </ rights >
37. < rights > Atribución 3.0 España </ rights >
38. < publisher > European Centre for Disease Prevention and Control (ECDC) </ publisher >
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  1. < subfield code =" a " > [Abstract]: Background: As increasing antibiotic resistance in Acinetobacter baumannii poses a global healthcare challenge, understanding its evolution is crucial for effective control strategies. Aim: We aimed to evaluate the epidemiology, antimicrobial susceptibility and main resistance mechanisms of Acinetobacter spp. in Spain in 2020, and to explore temporal trends of A. baumannii. Methods: We collected 199 single-patient Acinetobacter spp. clinical isolates in 2020 from 18 Spanish tertiary hospitals. Minimum inhibitory concentrations (MICs) for nine antimicrobials were determined. Short-read sequencing was performed for all isolates, and targeted long-read sequencing for A. baumannii. Resistance mechanisms, phylogenetics and clonality were assessed. Findings on resistance rates and infection types were compared with data from 2000 and 2010. Results: Cefiderocol and colistin exhibited the highest activity against A. baumannii, although colistin susceptibility has significantly declined over 2 decades. A. non-baumannii strains were highly susceptible to most tested antibiotics. Of the A. baumannii isolates, 47.5% (56/118) were multidrug-resistant (MDR). Phylogeny and clonal relationship analysis of A. baumannii revealed five prevalent international clones, notably IC2 (ST2, n = 52; ST745, n = 4) and IC1 (ST1, n = 14), and some episodes of clonal dissemination. Genes blaOXA-23, blaOXA-58 and blaOXA-24/40 were identified in 49 (41.5%), eight (6.8%) and one (0.8%) A. baumannii isolates, respectively. ISAba1 was found upstream of the gene (a blaOXA-51-like) in 10 isolates. Conclusions: The emergence of OXA-23-producing ST1 and ST2, the predominant MDR lineages, shows a pivotal shift in carbapenem-resistant A. baumannii (CRAB) epidemiology in Spain. Coupled with increased colistin resistance, these changes underscore notable alterations in regional antimicrobial resistance dynamics. </ subfield >
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19. < mods:abstract > [Abstract]: Background: As increasing antibiotic resistance in Acinetobacter baumannii poses a global healthcare challenge, understanding its evolution is crucial for effective control strategies. Aim: We aimed to evaluate the epidemiology, antimicrobial susceptibility and main resistance mechanisms of Acinetobacter spp. in Spain in 2020, and to explore temporal trends of A. baumannii. Methods: We collected 199 single-patient Acinetobacter spp. clinical isolates in 2020 from 18 Spanish tertiary hospitals. Minimum inhibitory concentrations (MICs) for nine antimicrobials were determined. Short-read sequencing was performed for all isolates, and targeted long-read sequencing for A. baumannii. Resistance mechanisms, phylogenetics and clonality were assessed. Findings on resistance rates and infection types were compared with data from 2000 and 2010. Results: Cefiderocol and colistin exhibited the highest activity against A. baumannii, although colistin susceptibility has significantly declined over 2 decades. A. non-baumannii strains were highly susceptible to most tested antibiotics. Of the A. baumannii isolates, 47.5% (56/118) were multidrug-resistant (MDR). Phylogeny and clonal relationship analysis of A. baumannii revealed five prevalent international clones, notably IC2 (ST2, n = 52; ST745, n = 4) and IC1 (ST1, n = 14), and some episodes of clonal dissemination. Genes blaOXA-23, blaOXA-58 and blaOXA-24/40 were identified in 49 (41.5%), eight (6.8%) and one (0.8%) A. baumannii isolates, respectively. ISAba1 was found upstream of the gene (a blaOXA-51-like) in 10 isolates. Conclusions: The emergence of OXA-23-producing ST1 and ST2, the predominant MDR lineages, shows a pivotal shift in carbapenem-resistant A. baumannii (CRAB) epidemiology in Spain. Coupled with increased colistin resistance, these changes underscore notable alterations in regional antimicrobial resistance dynamics. </ mods:abstract >
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25. < mods:subject >
  1. < mods:topic > Carbapenem-resistant </ mods:topic >
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  1. < mods:title > Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study </ mods:title >
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1. < dc:title > Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study </ dc:title >
2. < dc:creator > Lasarte-Monterrubio, Cristina </ dc:creator >
3. < dc:creator > Guijarro, Paula </ dc:creator >
4. < dc:creator > Alonso-Garcia, Isaac </ dc:creator >
5. < dc:creator > Outeda, Michelle </ dc:creator >
6. < dc:creator > Maceiras, Romina </ dc:creator >
7. < dc:creator > González-Pinto, Lucía </ dc:creator >
8. < dc:creator > Martínez-Guitián, Marta </ dc:creator >
9. < dc:creator > Fernández-Lozano, Carlos </ dc:creator >
10. < dc:creator > Vázquez-Ucha, Juan Carlos </ dc:creator >
11. < dc:creator > Bou, Germán </ dc:creator >
12. < dc:creator > Arca-Suárez, Jorge </ dc:creator >
13. < dc:creator > Beceiro, Alejandro </ dc:creator >
14. < dc:subject > Acinetobacter baumannii </ dc:subject >
15. < dc:subject > Carbapenem-resistant </ dc:subject >
16. < dc:subject > OXA-23 </ dc:subject >
17. < dc:subject > Nosocomial infections </ dc:subject >
18. < dcterms:abstract > [Abstract]: Background: As increasing antibiotic resistance in Acinetobacter baumannii poses a global healthcare challenge, understanding its evolution is crucial for effective control strategies. Aim: We aimed to evaluate the epidemiology, antimicrobial susceptibility and main resistance mechanisms of Acinetobacter spp. in Spain in 2020, and to explore temporal trends of A. baumannii. Methods: We collected 199 single-patient Acinetobacter spp. clinical isolates in 2020 from 18 Spanish tertiary hospitals. Minimum inhibitory concentrations (MICs) for nine antimicrobials were determined. Short-read sequencing was performed for all isolates, and targeted long-read sequencing for A. baumannii. Resistance mechanisms, phylogenetics and clonality were assessed. Findings on resistance rates and infection types were compared with data from 2000 and 2010. Results: Cefiderocol and colistin exhibited the highest activity against A. baumannii, although colistin susceptibility has significantly declined over 2 decades. A. non-baumannii strains were highly susceptible to most tested antibiotics. Of the A. baumannii isolates, 47.5% (56/118) were multidrug-resistant (MDR). Phylogeny and clonal relationship analysis of A. baumannii revealed five prevalent international clones, notably IC2 (ST2, n = 52; ST745, n = 4) and IC1 (ST1, n = 14), and some episodes of clonal dissemination. Genes blaOXA-23, blaOXA-58 and blaOXA-24/40 were identified in 49 (41.5%), eight (6.8%) and one (0.8%) A. baumannii isolates, respectively. ISAba1 was found upstream of the gene (a blaOXA-51-like) in 10 isolates. Conclusions: The emergence of OXA-23-producing ST1 and ST2, the predominant MDR lineages, shows a pivotal shift in carbapenem-resistant A. baumannii (CRAB) epidemiology in Spain. Coupled with increased colistin resistance, these changes underscore notable alterations in regional antimicrobial resistance dynamics. </ dcterms:abstract >
19. < dcterms:dateAccepted > 2024-07-08T09:48:59Z </ dcterms:dateAccepted >
20. < dcterms:available > 2024-07-08T09:48:59Z </ dcterms:available >
21. < dcterms:created > 2024-07-08T09:48:59Z </ dcterms:created >
22. < dcterms:issued > 2024-04-11 </ dcterms:issued >
23. < dc:type > info:eu-repo/semantics/article </ dc:type >
24. < dc:identifier > Lasarte-Monterrubio Cristina, Guijarro-Sánchez Paula, Alonso-Garcia Isaac, Outeda Michelle, Maceiras Romina, González-Pinto Lucia, Martínez-Guitián Marta, Fernández-Lozano Carlos, Vázquez-Ucha Juan Carlos, Bou German, Arca-Suárez Jorge, Beceiro Alejandro. Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study. Euro Surveill. 2024;29(15):pii=2300352. https://doi.org/10.2807/1560-7917.ES.2024.29.15.2300352 </ dc:identifier >
25. < dc:identifier > 1560-7917 </ dc:identifier >
26. < dc:identifier > http://hdl.handle.net/2183/37791 </ dc:identifier >
27. < dc:language > eng </ dc:language >
28. < dc:relation > https://doi.org/10.2807/1560-7917.ES.2024.29.15.2300352 </ dc:relation >
29. < dc:relation > info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F01212/ES/DESARROLLO Y EVALUACION DE NUEVAS MOLECULAS ANTIMICROBIANAS DIRIGIDAS A PATOGENOS MULTIRRESISTENTES (INHIBIDORES DE ß-LACTAMASAS Y CONJUGADOS TETRACICLINAS-SIDEROFOROS). ESTUDIO NACIONAL ACINETOBACTER SPP/ </ dc:relation >
30. < dc:relation > info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PI23%2F00851/ES/Actividad in vivo de nuevos inhibidores de carbapenemasas frente a patógenos críticos multirresistentes: K. pneumoniae productor de carbapenemasas y P. aeruginosa. </ dc:relation >
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38. < dc:rights > Atribución 3.0 España </ dc:rights >
39. < dc:publisher > European Centre for Disease Prevention and Control (ECDC) </ dc:publisher >
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  1. < dc:title > Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study </ dc:title >
  2. < dc:creator > Lasarte-Monterrubio, Cristina </ dc:creator >
  3. < dc:creator > Guijarro, Paula </ dc:creator >
  4. < dc:creator > Alonso-Garcia, Isaac </ dc:creator >
  5. < dc:creator > Outeda, Michelle </ dc:creator >
  6. < dc:creator > Maceiras, Romina </ dc:creator >
  7. < dc:creator > González-Pinto, Lucía </ dc:creator >
  8. < dc:creator > Martínez-Guitián, Marta </ dc:creator >
  9. < dc:creator > Fernández-Lozano, Carlos </ dc:creator >
  10. < dc:creator > Vázquez-Ucha, Juan Carlos </ dc:creator >
  11. < dc:creator > Bou, Germán </ dc:creator >
  12. < dc:creator > Arca-Suárez, Jorge </ dc:creator >
  13. < dc:creator > Beceiro, Alejandro </ dc:creator >
  14. < dc:subject > Acinetobacter baumannii </ dc:subject >
  15. < dc:subject > Carbapenem-resistant </ dc:subject >
  16. < dc:subject > OXA-23 </ dc:subject >
  17. < dc:subject > Nosocomial infections </ dc:subject >
  18. < dc:description > [Abstract]: Background: As increasing antibiotic resistance in Acinetobacter baumannii poses a global healthcare challenge, understanding its evolution is crucial for effective control strategies. Aim: We aimed to evaluate the epidemiology, antimicrobial susceptibility and main resistance mechanisms of Acinetobacter spp. in Spain in 2020, and to explore temporal trends of A. baumannii. Methods: We collected 199 single-patient Acinetobacter spp. clinical isolates in 2020 from 18 Spanish tertiary hospitals. Minimum inhibitory concentrations (MICs) for nine antimicrobials were determined. Short-read sequencing was performed for all isolates, and targeted long-read sequencing for A. baumannii. Resistance mechanisms, phylogenetics and clonality were assessed. Findings on resistance rates and infection types were compared with data from 2000 and 2010. Results: Cefiderocol and colistin exhibited the highest activity against A. baumannii, although colistin susceptibility has significantly declined over 2 decades. A. non-baumannii strains were highly susceptible to most tested antibiotics. Of the A. baumannii isolates, 47.5% (56/118) were multidrug-resistant (MDR). Phylogeny and clonal relationship analysis of A. baumannii revealed five prevalent international clones, notably IC2 (ST2, n = 52; ST745, n = 4) and IC1 (ST1, n = 14), and some episodes of clonal dissemination. Genes blaOXA-23, blaOXA-58 and blaOXA-24/40 were identified in 49 (41.5%), eight (6.8%) and one (0.8%) A. baumannii isolates, respectively. ISAba1 was found upstream of the gene (a blaOXA-51-like) in 10 isolates. Conclusions: The emergence of OXA-23-producing ST1 and ST2, the predominant MDR lineages, shows a pivotal shift in carbapenem-resistant A. baumannii (CRAB) epidemiology in Spain. Coupled with increased colistin resistance, these changes underscore notable alterations in regional antimicrobial resistance dynamics. </ dc:description >
  19. < dc:date > 2024-07-08T09:48:59Z </ dc:date >
  20. < dc:date > 2024-07-08T09:48:59Z </ dc:date >
  21. < dc:date > 2024-04-11 </ dc:date >
  22. < dc:type > info:eu-repo/semantics/article </ dc:type >
  23. < dc:identifier > Lasarte-Monterrubio Cristina, Guijarro-Sánchez Paula, Alonso-Garcia Isaac, Outeda Michelle, Maceiras Romina, González-Pinto Lucia, Martínez-Guitián Marta, Fernández-Lozano Carlos, Vázquez-Ucha Juan Carlos, Bou German, Arca-Suárez Jorge, Beceiro Alejandro. Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study. Euro Surveill. 2024;29(15):pii=2300352. https://doi.org/10.2807/1560-7917.ES.2024.29.15.2300352 </ dc:identifier >
  24. < dc:identifier > 1560-7917 </ dc:identifier >
  25. < dc:identifier > http://hdl.handle.net/2183/37791 </ dc:identifier >
  26. < dc:language > eng </ dc:language >
  27. < dc:relation > https://doi.org/10.2807/1560-7917.ES.2024.29.15.2300352 </ dc:relation >
  28. < dc:relation > info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F01212/ES/DESARROLLO Y EVALUACION DE NUEVAS MOLECULAS ANTIMICROBIANAS DIRIGIDAS A PATOGENOS MULTIRRESISTENTES (INHIBIDORES DE ß-LACTAMASAS Y CONJUGADOS TETRACICLINAS-SIDEROFOROS). ESTUDIO NACIONAL ACINETOBACTER SPP/ </ dc:relation >
  29. < dc:relation > info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PI23%2F00851/ES/Actividad in vivo de nuevos inhibidores de carbapenemasas frente a patógenos críticos multirresistentes: K. pneumoniae productor de carbapenemasas y P. aeruginosa. </ dc:relation >
  30. < dc:relation > info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI21%2F00704/ES/VACUNAS AUXOTROFAS ORALES PARA LA ERRADICACION DE BACTERIAS INTESTINALES: COLONIZACIÓN INTESTINAL POR KLEBSIELLA PNEUMONIAE MULTIRRESISTENTE COMO MODELO/ </ dc:relation >
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  37. < dc:rights > Atribución 3.0 España </ dc:rights >
  38. < dc:publisher > European Centre for Disease Prevention and Control (ECDC) </ dc:publisher >
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