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3,3′,4,5′-Tetramethoxy-trans-stilbene improves insulin resistance by activating the IRS/PI3K/Akt pathway and inhibiting oxidative stress

Identificadores del recurso

Current Issues In Molecular Biology, 44(5): 2175-2185 (2022)

14673037

http://hdl.handle.net/11093/3599

10.3390/cimb44050147

https://www.mdpi.com/1467-3045/44/5/147

Procedência

Ficha

Título:: 3,3′,4,5′-Tetramethoxy-trans-stilbene improves insulin resistance by activating the IRS/PI3K/Akt pathway and inhibiting oxidative stress
Tema:: 2302.14 Glúcidos; 2302 Bioquímica; 3309.03 Antioxidantes en Los Alimentos
Descrição:: The potential anti-diabetic effect of resveratrol derivative, 3,3′,4,5′-tetramethoxy-trans-stilbene (3,3′,4,5′-TMS) and its underlying mechanism in high glucose (HG) and dexamethasone (DXMS)-stimulated insulin-resistant HepG2 cells (IR-HepG2) were investigated. 3,3′,4,5′-TMS did not reduce the cell viability of IR-HepG2 cells at the concentrations of 0.5–10 µM. 3,3′,4,5′-TMS increased the potential of glucose consumption and glycogen synthesis in a concentration-dependent manner in IR-HepG2 cells. 3,3′,4,5′-TMS ameliorated insulin resistance by enhancing the phosphorylation of glycogen synthase kinase 3 beta (GSK3β), inhibiting phosphorylation of insulin receptor substrate-1 (IRS-1), and activating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway in IR-HepG2 cells. Furthermore, 3,3′,4,5′-TMS significantly suppressed levels of reactive oxygen species (ROS) with up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2) expression. To conclude, the beneficial effect of 3,3′,4,5′-TMS against insulin resistance to increase glucose consumption and glycogen synthesis was mediated through activation of IRS/PI3K/Akt signaling pathways in the IR-HepG2 cells, accomplished with anti-oxidative activity through up-regulation of Nrf2.; University of Macau | Ref. SRG2019-00154-ICMS; University of Macau | Ref. MYRG2019-00157-ICMS; University of Macau | Ref. MYRG2018-00169-ICMS; Science and Technology Development Fund | Ref. 0117/2020/A; Science and Technology Development Fund | Ref. SKL-QRCM(UM)-2020–2022; Science and Technology Development Fund | Ref. 0098/2020/A; Ministerio de Ciencia e Innovación | Ref. RYC2020-030365-I
Idioma:: English
Relação:: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RYC2020-030365-I/ES
Autor/Produtor:: Tan, Yi; Miao, Lingchao; Xiao , Jianbo; Cheang, Wai San
Editor:: Current Issues In Molecular Biology; Química analítica e alimentaria; Investigacións Agrarias e Alimentarias
Direitos:: Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/; openAccess
Data:: 2022-06-21T12:09:18Z; 2022-05-12; 2022-06-21T08:37:49Z
Tipo de recurso:: article

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1. < dc:title > 3,3′,4,5′-Tetramethoxy-trans-stilbene improves insulin resistance by activating the IRS/PI3K/Akt pathway and inhibiting oxidative stress </ dc:title >
2. < dc:creator > Tan, Yi </ dc:creator >
3. < dc:creator > Miao, Lingchao </ dc:creator >
4. < dc:creator > Xiao , Jianbo </ dc:creator >
5. < dc:creator > Cheang, Wai San </ dc:creator >
6. < dc:subject > 2302.14 Glúcidos </ dc:subject >
7. < dc:subject > 2302 Bioquímica </ dc:subject >
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9. < dc:description > The potential anti-diabetic effect of resveratrol derivative, 3,3′,4,5′-tetramethoxy-trans-stilbene (3,3′,4,5′-TMS) and its underlying mechanism in high glucose (HG) and dexamethasone (DXMS)-stimulated insulin-resistant HepG2 cells (IR-HepG2) were investigated. 3,3′,4,5′-TMS did not reduce the cell viability of IR-HepG2 cells at the concentrations of 0.5–10 µM. 3,3′,4,5′-TMS increased the potential of glucose consumption and glycogen synthesis in a concentration-dependent manner in IR-HepG2 cells. 3,3′,4,5′-TMS ameliorated insulin resistance by enhancing the phosphorylation of glycogen synthase kinase 3 beta (GSK3β), inhibiting phosphorylation of insulin receptor substrate-1 (IRS-1), and activating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway in IR-HepG2 cells. Furthermore, 3,3′,4,5′-TMS significantly suppressed levels of reactive oxygen species (ROS) with up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2) expression. To conclude, the beneficial effect of 3,3′,4,5′-TMS against insulin resistance to increase glucose consumption and glycogen synthesis was mediated through activation of IRS/PI3K/Akt signaling pathways in the IR-HepG2 cells, accomplished with anti-oxidative activity through up-regulation of Nrf2. </ dc:description >
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